长期专注于鼻咽癌的临床诊疗及其相关转化研究,擅长鼻咽癌的放疗、化疗、手术及其综合治疗,尤其是复发、转移、坏死鼻咽癌等难治性鼻咽癌的临床综合治疗。发表第一/并列第一/通讯作者SCI论文30余篇,总IF超过100,最高IF为11.753,最高单篇引频85次;主持国家级、省部级和校级等各类科研基金项目近20项,总经费800余万;先后在美国耳鼻咽喉-头颈外科年会、欧洲放射肿瘤年会等国际国内著名学术会议上做主题发言10余次;并分别入选中山大学肿瘤防治中心优秀青年人才培养计划(2009年度)、中山大学优秀青年教师培养计划(2010年度)、教育部“新世纪优秀人才支持计划”(2012年度)和中山大学肿瘤防治中心特支计划“临床医学科学家”(2015年度)。主要学术贡献有:
1.在调强放疗方面,通过迄今世界上最大宗(7081例)初治鼻咽癌病例回顾性分析,证明调强放疗相对于传统二维放疗,可以显著提高初治鼻咽癌的无局部复发生存率和无进展生存率。
3.在复发鼻咽癌方面,率先在国内国际系统报道了经鼻内镜鼻咽切除术治疗局部复发鼻咽癌的新技术,术后联合自主创新的带血管蒂鼻腔粘骨膜瓣修复术进行一期伤口修复,彻底解决复发鼻咽癌肿瘤难以切除、伤口难以愈合的科学难题,从而为局部复发鼻咽癌的挽救性外科治疗提供了一个创新、微创、系统的治疗模式,显著提高了局部复发鼻咽癌的生存率和生存质量。
5.在转移鼻咽癌方面,通过迄今世界上最大宗(977例)和多中心初治远处转移鼻咽癌病例研究,成功地将远处转移转移鼻咽癌分成低危、中危和高危三个亚组,并发现在全身化疗的基础上,联合局部区域放疗有助于提高低危和中危的患者的生存率。
近五年发表的第一/并列第一/通讯作者论文(#代表并列第一,*代表通讯作者):
1.Qian Zhu, Xiong Zou, Rui You, Rou Jiang, Men-Xia Zhang, You-Ping Liu, Chao-Nan Qian, Hai-Qiang Mai, Ming-Huang Hong, Lin Guo*, Ming-Yuan Chen*. Establishment of an innovative staging system for extramedullary plasmacytoma. BMC Cancer. 2016 Oct 8;16(1):777.
2.Meng-Xia Zhang, Yi-Jun Hua, Hai-Yun Wang, Ling Zhou, Hai-Qiang Mai, Xiang Guo, Chong Zhao, Wen-Lin Huang, Ming-Huang Hong*, Ming-Yuan Chen*. Long Term Prognostic Implication and therapeutic target role of Hexokinase II in Patients with Nasopharyngeal Carcinoma. Oncotarget. 2016 19;7(16):21287-97.
3.Jiang R, You R, Pei XQ, Zou X, Zhang MX, Wang TM, Sun R, Luo DH, Huang PY, Chen QY, Hua YJ, Tang LQ, Guo L, Mo HY, Qian CN, Mai HQ, Hong MH, Cai HM*, Ming-Yuan Chen*. Development of a ten-signature classifier using a support vector machine integrated approach to subdivide the M1 stage into M1a and M1b stages of nasopharyngeal carcinoma with synchronous metastases to better predict patients' survival. Oncotarget. 2016, 19;7(3):3645-57.
4.Deng CC, Xu M, Li J, Luo XL, Zhu YJ, Jiang R, Zhang MX, Lei JJ, Lian YF, Zou X, You R, Chen LZ, Feng QS, Bei JX, Ming-Yuan Chen*, Zeng YX*. Unconjugated Bilirubin Is a Novel Prognostic Biomarker for Nasopharyngeal Carcinoma and Inhibits Its Metastasis via Antioxidation Activity. Cancer Prev Res (Phila). 2016, 9(2):180-8.
5.Sang Y#, Chen MY#, Luo D#, Zhang RH, Wang L, Li M, Luo R, Qian CN, Shao JY, Zeng YX, Kang T. TEL2 suppresses metastasis by down-regulating SERPINE1 in nasopharyngeal carcinoma. Oncotarget. 2015 Oct 6;6(30):29240-53.
6.Zhang MX, Li J, Shen GP, Zou X, Xu JJ, Jiang R, You R, Hua YJ, Sun Y, Ma J, Hong MH, Chen MY*. Intensity-modulated radiotherapy prolongs the survival of patients with nasopharyngeal carcinoma compared with conventional two-dimensional radiotherapy: A 10-year experience with a large cohort and long follow-up. Eur J Cancer. 2015 Nov;51(17):2587-95.
7.Jiang R, Cai XY, Yang ZH, Yan Y, Zou X, Guo L, Sun R, Luo DH, Chen QY, Huang PY, Xiang YQ, Lu X, Wang L, Xia WX, Mai HQ, Chen MY*. Elevated peripheral blood lymphocyte-to-monocyte ratio predicts a favorable prognosis in the patients with metastatic nasopharyngeal carcinoma. Chin J Cancer. 2015 Jun 10;34(6):237-46.
8.Rui You, Xiong Zou, Rou Jiang, Lin-Quan Tang, Wei-Dong Zhang, Li Li, Meng-Xia Zhang, Guo-Ping Shen, Ling Guo, Xiang Guo, Chao-Nan Qian, Hai-Qiang Mai, Jun Ma, Ming-Huang Hong, Ming-Yuan Chen*. New Surgical Staging System for Patients with Recurrent Nasopharyngeal Carcinoma based on the AJCC/UICC rTNM Classification System. European Journal of Cancer. 2015 Sep;51(13):1771-9.
9.Rui You, Xiong Zou, Yi-Jun Hua, Fei Han, Li Li, Chong Zhao, Ming-Huang Hong, Ming-Yuan Chen*. Salvage Endoscopic Nasopharyngectomy is Superior to Intensity-Modulated Radiation Therapy for Local Recurrence of Selected T1-T3 Nasopharyngeal Carcinoma --- a Case-Matched Comparison. Radiotherapy & Oncology. 2015 Jun;115(3):399-406.
10.Rou Jiang, Xiong Zou, Wen Hu, Yu-Ying Fan, Yue Yan, Meng-Xia Zhang, Rui You, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Pei-Yu Huang, Yi-Jun Hua, Ling Guo, Ming-Yuan Chen*. The elevated pretreatment platelet-to-lymphocyte ratio predicts poor outcome in nasopharyngeal carcinoma patients. Tumor Biology. 2015 Sep;36(10):7775-87.
11.Rou Jiang, Zhong-Han Yang, Xiu-Yu Cai, Yue Yan, Xiong Zou, Ling Guo, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Pei-Yu Huang, Yan-Qun Xiang, Xing Lu, Lin Wang, Wei-Xiong Xia, Hai-Qiang Mai, Ming-Yuan Chen*. The elevated peripheral blood lymphocyte/monocyte ratio predicts favorable prognosis in metastatic nasopharyngeal carcinoma. Chinese Journal of Cancer. 2015 Jun 10;34(1):23.
12.Jing Li, Xiong Zou, Yun-Long Wu, Jing-Cui Guo, Jing-Ping Yun, Miao Xu, Qi-Sheng Feng, Li-Zhen Chen, Jin-Xin Bei, Yi-Xin Zeng, Ming-Yuan Chen*. A comparison between the sixth and seventh editions of the UICC/AJCC staging system for nasopharyngeal carcinoma in a Chinese cohort. PLoS One. 2014 Dec 23;9(12):e116261.
13.Xiong Zou, Fei Han, Wen-Juan Ma, Man-Quan Deng, Rou Jiang, Lin Guo, Qing Liu, Hai-Qiang Mai, Ming-Huang Hong, Ming-Yuan Chen*. Salvage endoscopic nasopharyngectomy and intensity-modulated radiotherapy versus conventional radiotherapy in treating locally recurrent nasopharyngeal carcinoma. Head Neck. 2015 Aug;37(8):1108-15.
14.Rou Jiang, Zhong-Han Yang, Dong-Hua Luo, Lin Guo, Rui Sun, Qiu-Yan Chen, Pei-Yu Huang, Fang Qiu, Xiong Zou, Ka-Jia Cao, Hai-Qiang Mai, Xiang Guo, Chao-Nan Qian, Ming-Huang Hong, Ming-Yuan Chen*. Elevated apolipoprotein A-I levels are associated with favorable prognosis in metastatic nasopharyngeal carcinoma. Med Oncol. 2014 Aug;31(8):80.
15.Yi Sang, Li Wang, Jian-Jun Tang, Mei-Fang Zhang, Meng-Xia Zhang, Xia Liu, Ru-Hua Zhang, Tie-Bang Kang, Ming-Yuan Chen*. Oncogenic roles of carbonic anhydrase IX in human nasopharyngeal carcinoma. Int J Clin Exp Pathol. 2014, 7(6):2942-9.
16.Xiang-Bo Wan, Rou Jiang, Fang-Yun Xie, Zhen-Yu Qi, Ai-Ju Li, Wei-Jun Ye, Yi-Jun Hua, Yu-Liang Zhu, Xiong Zou, Ling Guo, Hai-Qiang Mai, Xiang Guo, Ming-Huang Hong, Ming-Yuan Chen*. Endoscope-guided Interstitial Intensity -Modulated Brachytherapy and Intracavitary Brachytherapy as Boost Radiation for Primary Early T Stage Nasopharyngeal Carcinoma. PLoS One. 2014 Mar 3;9(3):e90048. 2014.
17.Ming-Yuan Chen; Yi-Jun Hua; Hai-Qiang Mai, et al. Clinical findings and imaging features of 67 nasopharyngeal carcinoma patients with postradiation nasopharyngeal necrosis (PRNN). Chin J Cancer. 2013, 32(10):533-8.
18.Chen Mingyuan*, Jiang Rou, Guo Ling, Zou Xiong, Liu Qin, Sun Rui, Qiu Fang, Xia Zongjun, Huang Haiqiang, Zhang Li, Hong Minghuang, Mai Haiqiang, Qian Chaonan. Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis. Chin J Cancer. 2013, 32(11):604-13.
19.Ming-Yuan Chen*, Rou Jiang, Ling Guo, Pei-Yu Huang, Dong-Hua Luo, Xiong Zou, Men-Xia Zhang, Rui Sun, Yi-Jun Hua, Xing Lv, Lin Wang, Hai-Qiang Mai, Ming-Huang Hong. Impact of Local Radiotherapy of Bone Lesions on the Survival Risk in Nasopharyngeal Carcinoma Patients with Bone Metastasis. Journal of Sun Yat-Sen university (Medical sciences). 2013, 34(6):979-985.
20.Jing Li, Rou Jiang, Wu-Shen Liu, Qing Liu, Miao Xu, Qi-Sheng Feng, Li-Zhen Chen, Jin-Xin Bei, Ming-Yuan Chen*, Yi-Xin Zeng*. A Large Cohort Study Reveals the Association of Elevated Peripheral Blood Lymphocyte-to-Monocyte Ratio with Favorable Prognosis in Nasopharyngeal Carcinoma. PLoS One. 2013 Dec 27;8(12):e83069.
21.Wang Tiantian#, Cao Qinghua#, Chen Mingyuan#, Xia Qing, Fan Xingjuan, Ma Xiaokun, Lin Qu, Jia Changchang, Dong Min, Ruan Danyun, Lin Zexiao, Wen Jingyun, Wei Li, Li Xing, Chen Zhanhong, Wang Lei, Wu Xiangyuan, Wan Xiangbo. Beclin 1 deficiency correlated with lymph node metastasis, predicts a distinct outcome in intrahepatic and extrahepatic cholangiocarcinoma. PLoS One. 2013 Nov 26;8(11):e80317.
22.Ming-Yuan Chen; Yi-Jun Hua; Xiang-Bo Wan; Rui Sun; Pei-Yu Huang; Yan-Qun Xiang; Ling Guo; Hao-Yuan; Yue Yang; Ming-Huang Hong. A posteriorly pedicled middle turbinate mucoperiosteal flap resurfacing nasopharynx after endoscopic nasopharyngectomy for recurrent NPC. Otolaryngology-Head and Neck Surgery, 2012, 146(3):409-11.
23.Ming-Yuan Chen*, Sun-Lan Wang, Yu-Liang Zhu, Fang Qiu, Yan-Qiu Chen, Rou Jiang, Ca-Jia, Chao, Hai-Qiang Mai, Ming-Huang Hong*. Use of a posterior pedicle nasal septum and floor mucoperiosteum flap to resurface the nasopharynx after endoscopic nasopharyngectomy for recurrent nasopharyngeal carcinoma. Head & Neck, 2012, 34(10):1383-8.
24.Xiang-Bo Wan#, Xin-Juan Fan#, Ming-Yuan Chen#, Jin Xiang, Pei-Yu Huang, Ling Guo, Xiang-Yuan Wu, Jie Xu, Zi-Jie Long, Yan Zhao, Wei-Hua Zhou, Hai-Qiang Mai, Quentin Liu, Ming-Huang Hong. Elevated Beclin 1 expression is correlated with HIF-1a in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy, 2010, 6(3):395-404
更新时间:2016年12月6日